EFFECT OF TP53 DEFICIENCY AND KRAS SIGNALING ON THE BIOENERGETICS OF COLON CANCER CELLS IN RESPONSE TO DIFFERENT SUBSTRATES: A SINGLE CELL STUDY

Effect of TP53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in response to different substrates: A single cell study

Metabolic reprogramming is a hallmark of cancer.Somatic mutations in genes involved in oncogenic signaling pathways, including KRAS and TP53, rewire the metabolic machinery in cancer cells.We here set out to determine, at the single cell level, metabolic signatures in human colon cancer cells engineered to express combinations of activating KRAS VA

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Mental health awareness, stigma, and help-seeking attitudes among Albanian university students in the Western Balkans: a qualitative study

IntroductionThe significance of mental health and its impact on overall well-being is increasingly acknowledged across various sectors, including higher education.However, despite this growing recognition, the stigma associated with mental health issues and related help-seeking, particularly within certain cultural groups and socio-economic context

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